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Endpoint Security Guide

How to protect laptops, desktops, mobile devices and servers from ransomware, credential theft, and zero-day exploits โ€” using Microsoft Defender for Endpoint.

Prepared by
De4sec Technology
Contact
support@de4sec.technology
Edition
2026 ยท Updated March
CONFIDENTIAL ยท FOR CLIENT USE ONLY
Contents
  1. Why Endpoints Are the Primary Attack Surface
  2. Microsoft Defender for Endpoint
  3. Deployment Configuration
  4. Monitoring and Alert Response
  5. Endpoint Security for Mobile Devices
  6. De4sec Endpoint Security Service
01

Why Endpoints Are the Primary Attack Surface

Endpoints โ€” the laptops, desktops, mobile devices and servers that users interact with โ€” are where the vast majority of attacks begin. Phishing emails land in mailboxes. Malicious downloads execute on workstations. Ransomware spreads device to device across the network.

Traditional antivirus detected known malware by signature. Modern attacks use fileless techniques, living-off-the-land binaries, and zero-day exploits that signatures can't detect. Modern endpoint protection uses behavioural analysis โ€” detecting what the malware does, not what it looks like.

Modern endpoint security is not about detecting viruses. It's about detecting malicious behaviour โ€” and stopping it before damage occurs.

02

Microsoft Defender for Endpoint

Microsoft Defender for Endpoint (MDE) is the enterprise EDR platform included with Microsoft 365 Business Premium and most E3/E5 plans. For businesses already using Microsoft 365, it's the most cost-effective endpoint protection platform available.

Key capabilities

Endpoint Detection & Response (EDR)
Behavioural detection that identifies attack patterns โ€” not just known malware signatures. Alerts on suspicious process trees, unusual network connections, and attacker tools.
Automated Investigation & Remediation
When an alert fires, Defender automatically investigates the root cause and can automatically remediate โ€” quarantine files, isolate devices, reverse changes.
Attack Surface Reduction (ASR)
Rules that block specific attacker techniques โ€” blocking Office applications from spawning child processes, blocking executable content from email, preventing credential theft from LSASS.
Threat & Vulnerability Management
Continuous assessment of endpoint vulnerability posture โ€” which devices have which vulnerabilities, with prioritised remediation guidance.
03

Deployment Configuration

Onboarding devices

โœ“Onboard all Windows devices via Intune (Group Policy or Configuration Manager for larger environments)
โœ“macOS onboarding via Intune MDM enrollment
โœ“Mobile devices (iOS/Android) via Intune MAM (app-level protection) or MDM enrollment

Security baseline

โœ“Enable cloud-delivered protection โ€” real-time cloud lookups for unknown files
โœ“Enable automatic sample submission โ€” suspected malware sent for analysis
โœ“Enable tamper protection โ€” prevents attackers from disabling Defender
โœ“Enable PUA protection โ€” block potentially unwanted applications
โœ“Set EDR in block mode โ€” Defender takes remediation action even if another AV is primary

Attack Surface Reduction rules โ€” recommended for SMB

โœ“Block Office applications from creating executable content
โœ“Block execution of potentially obfuscated scripts
โœ“Block Win32 API calls from Office macros
โœ“Block credential stealing from LSASS
โœ“Use advanced protection against ransomware
04

Monitoring and Alert Response

Defender for Endpoint generates alerts across multiple severity levels. The response approach varies by severity โ€” but all alerts should be investigated.

SeverityExamplesResponse
InformationalUnusual login time, new deviceReview weekly in Security portal
LowSuspicious script execution, blocked malwareInvestigate within 24 hours
MediumCredential access attempt, lateral movementInvestigate within 4 hours
HighActive ransomware, data exfiltrationImmediate โ€” escalate to De4sec now

Microsoft 365 Defender portal

All endpoint alerts, incidents, and investigations are centralised in the Microsoft 365 Defender portal (security.microsoft.com). De4sec provides managed monitoring of this portal โ€” reviewing alerts, investigating incidents, and responding on behalf of clients.

05

Endpoint Security for Mobile Devices

Mobile devices โ€” particularly personally-owned phones used for work email and Teams โ€” represent a significant gap in most endpoint security strategies. The device isn't enrolled in Intune, doesn't have EDR, and may access corporate data with no security controls.

Mobile Application Management (MAM)

โœ“Intune MAM without full device enrollment โ€” apply data protection policies to specific apps only
โœ“Require PIN to open Outlook, Teams, SharePoint apps
โœ“Prevent copy/paste from corporate apps to personal apps
โœ“Remote wipe of corporate data from personal device if device is lost or employee leaves

Conditional Access for mobile

โœ“Block unmanaged mobile devices from accessing sensitive data
โœ“Require Intune App Protection Policy (APP) compliance for mobile access
โœ“Allow browser-only access from unmanaged devices โ€” no downloads
06

De4sec Endpoint Security Service

De4sec provides Microsoft Defender for Endpoint deployment and managed monitoring as part of our managed IT and cybersecurity service.

Deployment
Onboard all devices, configure security baseline, deploy ASR rules, integrate with Intune compliance policies.
Managed Monitoring
24/5 alert monitoring via Microsoft Defender portal. Critical alerts escalated immediately. Weekly review of informational and low-severity alerts.
Incident Response
When a high-severity alert fires, De4sec investigates, contains, and remediates. Post-incident report provided with root cause analysis.
Reporting
Monthly endpoint security report: device compliance, patch status, alerts by severity, open vulnerabilities.
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